Study participant Sean O’Connell is given a shot in this undated handout photo. Canadian researchers have launched a study to determine if a century-old vaccine against tuberculosis can offer some protection against COVID-19. Investigators at the University Health Network in Toronto say they hope to test a theory that Bacille Calmette Guerin, or BCG, can reduce the incidence and severity of COVID-19 infection. THE CANADIAN PRESS/HO - University Health Network

Canadian researchers explore whether TB vaccine offers COVID-19 protection

The trial is open to police, fire and health-care workers who are at greater risk of COVID-19 exposure

Canadian researchers have launched a study to determine if a century-old vaccine against tuberculosis can offer some protection against COVID-19.

Investigators at the University Health Network in Toronto say they hope to test a theory that Bacille Calmette Guerin, or BCG, can reduce the incidence and severity of COVID-19 infection.

The trial is open to police, fire and health-care workers who are at greater risk of COVID-19 exposure, with researchers hoping to recruit more than 3,600 participants.

Principal co-investigator Dr. Alexandre Zlotta says that if the inexpensive vaccine proves helpful, it can be rapidly deployed to offer temporary protection until a COVID-specific vaccine is widely available.

While BCG continues to be used in European and developing countries, Canada discontinued routine use in the early 1970s, according to Toronto Public Health.

Tuberculosis cases in Canada are among the lowest in the world, although certain vulnerable populations are at higher risk for the infectious, bacterial disease.

Dubbed “COBRA,” the double-blind placebo-controlled study is unfolding alongside trials in Germany and the United States. Experts expect to release results in May 2021.

Interest in BCG emerged early in the pandemic when researchers noticed some countries with higher rates of BCG coverage also had significantly lower rates of COVID-19 deaths. But more recent analysis reflecting the pandemic’s movement across the globe bucks that idea.

“Lack of evidence for BCG vaccine protection from severe COVID-19,” states the headline of a letter published in the Proceedings of the National Academy of Sciences on Sept. 29.

Citing updated analysis based on data from the Johns Hopkins University Coronavirus Resource Center, the study notes Bolivia, Panama, Columbia, Peru, Brazil, Mexico and South Africa had the largest increases in COVID-19 deaths on Aug. 1, even though the countries also have high BCG coverage.

The letter concludes by saying ongoing randomized controlled trials should provide more concrete answers.

UHN says the Canadian study uses an improved version of the vaccine, which researchers expect “will help muster a stronger immune response.”

“The big advantage here is this vaccine has been given to billions of people around the world in the past decades,” Zlotta says in a release.

“It is safe and readily available. If the study is successful, this could become an important strategy to control the secondary waves of the pandemic.”

The study is being funded by The Princess Margaret Cancer Foundation.

Cassandra Szklarski, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

RCMP. (Phil McLachlan - Black Press Media file)
Penticton RCMP cleared of wrongdoing after man seriously injured in custody

B.C.’s police watchdog found no evidence of harm caused by police in Sept. 21 incident

Apex Mountain Resort received 35 centimetres of fresh snow over the weekend, prompting some to head out for some early season turns. (Apex Mountain Resort / Facebook)
Stay off the mountain: Apex warns of early season dangers

Recreational use of the mountain before opening day comes with serious risks

The Penticton Indian Band is opposing any hunting of local big horn sheep which are an at-risk population. (submitted photo)
Penticton Indian Band oppose big horn sheep hunts

Local big horn sheep are an at-risk population

A house on Highway 3A caught fire Sunday evening, Oct. 25, 2020.
House fire on Highway 3A in Keremeos

Neighbours acted quickly to help save home

x
Morning Start: Bubble wrap was originally intended to be wallpaper

Your morning start for Monday, Oct. 26, 2020

FILE – Provincial Health Officer Dr. Bonnie Henry provides the latest update on the COVID-19 pandemic in the province during a press conference in the press theatre at Legislature in Victoria, B.C., on Thursday, October 22, 2020. THE CANADIAN PRESS/Chad Hipolito
B.C. shatters COVID-19 records with 817 weekend cases; masks now expected indoors

Three people have died over the past three reporting periods

Salmon Arm RCMP responded to a seven-vehicle chain reaction collision early Monday morning, Oct. 26. (File photo)
One person injured in seven-vehicle chain-reaction collision in Salmon Arm

Snow packed to ice, speed contributing factors behind collisions

RCMP responded to a single-vehicle collision on Highway 1 east of Salmon Arm early Monday, Oct. 26, 2020. (File photo)
Salmon Arm man killed in collision on Highway 1

RCMP say slippery road conditions contributing factor behind collision

Jordan Naterer, 25, was last seen Saturday Oct. 10. He planned a hike in the Manning Park area, and has not been seen since. Photo Facebook.
Parents not giving up, after official search for Manning Park hiker suspended again

‘We are determined, but eventually the money is going to run out.’

RCMP have released more details regarding what led up to an arrest caught on video in Williams Lake Sunday, Oct. 26. (Facebook video screenshot)
Review launched after ‘high-risk, multi-jurisdictional’ chase, arrest in Williams Lake

RCMP launching a full review and code of conduct investigation

(Pxfuel)
B.C. limits events in private homes to household, plus ‘safe six’ amid COVID-19 surge

Henry issued a public health order limiting private gatherings to one household, plus a group of ‘safe six’ only

B.C. Liberal Leader Andrew Wilkinson speaks during a drive-in car rally campaign stop at a tour bus operator, in Delta, Saturday, Oct. 17, 2020. THE CANADIAN PRESS/Darryl Dyck
Andrew Wilkinson stepping down as B.C. Liberal leader

Will stay on until the next party leader is chosen

VicPD and B.C. Conservation Officer Service teamed up to free two bucks who were entangled in a fishing net and dragging a wheelbarrow sized piece of driftwood behind them. (VicPD)
VIDEO: Police, B.C. Conservation help two bucks caught in one fishing net

Bucks were also dragging a wheelbarrow sized piece of driftwood behind them

Friends and family of Sonya Riome, 35, are confirming she died in the fire. (Submitted)
Woman dies in weekend Revelstoke house fire

The fire gutted the property

Most Read